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In my experience, the most readable response format are replys on some link aggregator (lemmy, hn, …) and a link to that thread in the original post.
Some bloggers have experimented and used Mastodon as a medium to comments on their blog posts. Works quite well.
https://danielpecos.com/2022/12/25/mastodon-as-comment-system-for-your-static-blog/