Multiple regulatory bodies are going to get disbanded. The EPA is unlikely to survive, whole departments of the FDA are about to get gutted. Anything involving industrial safety is going to get its funding cut. Unconstitutional crackdowns on free and independent media is almost certain. Large scale damage to the functions of many government institutions can be expected. Massive economic damage due to reckless deregulation ( that’s even before they start putting tariffs on everything and wind up in multiple simultaneous trade wars). Funding for education and infrastructure maintenance will be reduced to allow tax cuts for the already wealthy. Massive loss of global influence and a massive gain in influence by hostile autocratic nations is also something you can expect.
I could go on and on but even if you were to assume they weren’t serious about project 2025 (if you haven’t read that you should) it’s real bad.
I’d love be as optimistic as you but unless Trump changes his mind the US will get a brainwormed fanatical anti-vaccier in charge of deciding which vaccines are safe to use. Even if the states don’t cooperate with trump’s agenda there are so many long standing federal institutions which till now you’ve never needed to think about that are about to get wrecked.