Her experience, while not the norm, is far from unusual, experts say.
Applegate disclosed the revelation on an episode of her podcast with Jamie Lynn Sigler, MeSsy, which centers on their lives with MS. (Sigler disclosed that she has relapsing-remitting multiple sclerosis, or RRMS, in 2016.) “In January of 2021, I had numbness in my toes, and that numbness grew to all of my legs,” Applegate recalled on the podcast. “And then the pain started.”


I don’t know how technically specific you’re trying to be here, but there are definitely treatments for some diseases that have major neurodegenerative effects, such as pernicious anemia.
For that one, the treatment is amazingly cheap (B12 injections), but most US doctors are decades behind in understanding and applying it.
Sounds like YouTube medicine.