As US health secretary, Robert F. Kennedy Jr. has drawn a lot of attention for promoting pseudoscience and disproven theories, especially on vaccines. He is using that playbook on another major public health issue: gun violence, which remains the leading cause of death for kids in America. When it comes to school shootings and other mass shootings, here’s what RFK Jr. wants you to believe: It’s not the guns, he argues, it’s the pills.

The fringe theory that antidepressants can cause people to turn violent has been around for decades, focused primarily on selective serotonin reuptake inhibitors, or SSRIs, which are the most common class of these drugs. But extensive research by mental health and violence prevention experts has found no credible evidence that antidepressants cause or contribute to mass shootings.

The generalized claim that SSRIs can make people violent—and that they supposedly gave rise to the shootings epidemic—traces in part to an unscientific anti-Prozac campaign in the 1990s from the Church of Scientology and gained some traction in online forums after the Columbine High School massacre in 1999. Disgraced conspiracy theorist Alex Jones, who helped create a miasma of lies claiming that the 2012 mass shooting at Sandy Hook Elementary School was faked, has also peddled the theory.

Proponents of the SSRI theory use anecdotal, often unconfirmed details about shooters’ health histories to argue causation. But multiple studies from experts in psychiatry, law enforcement, and public health show that the theory has no merit. Data on shooters spanning more than a decade from the FBI’s Behavioral Analysis Unit has been used specifically to examine the claim that psychiatric drugs are at the root of school shootings; independent researchers concluded from the FBI data that “most school shooters were not previously treated with psychotropic medications—and even when they were, no direct or causal association was found.”

  • AmbitiousProcess (they/them)@piefed.social
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    11 hours ago

    You say that, but those were double blind clinical trials.

    Yes. They were trials done to one of the highest standards we have for assessing the outcomes of drugs. Double blind studies help to prevent the biases you seem to think that type of study causes. Do you know how these studies even work or why we do them?

    The fda is led by former drug company officials and let the research firms stroke the follow up studies through.

    The FDA does not control if these papers get published or not, as PubMed has nothing to do with the FDA, and the FDA has no say in how follow-up studies are done on patients using already-approved drugs on the market.

    1 percent better than placebo

    Did you not even look at the resources I sent? Here’s the core piece I think you really need to actually pay attention to:

    Pooled estimates of efficacy data showed an RR of 1.24, 95% CI 1.11-1.38 in favour of TCAs against placebo. For SSRIs this was 1.28, 95% CI 1.15 to 1.43.

    The 1.24 and 1.28 are the relative risk ratios for treatment with meds, vs placebo. Essentially 1.24 means 24%, 1.28 means 28%. Those percentages being… the likelihood the treatment would treat the underlying symptoms, relative to a placebo.

    24% and 28% are not 1%.

    run by the firms they hired

    The companies making these drugs did not hire these researchers. The closest thing they have to influence on their research is funding a conference-focused group that does outreach and education for researchers, which in turn derives only a portion of its funding from one drug manufacturer. (which you would know if you looked at the paper itself and read the clearly visible conflict of interest statement that all good researchers publish with their papers)

    I don’t know about you, but if I’m a large group of independent researchers, I’m not going to collectively entirely fabricate fourteen studies over many years, fabricate the analysis in a metanalysis of those works, then publish it with my name attached… because I get to attend a conference for free sometimes and get pitched medical tools???

    This isn’t justifiable criticism of the pharmaceutical industry, this is just anti pharmaceutical industry sentiment packaged in whatever words sound bad enough to you regardless of what is observably in reality. I have my problems with the pharmaceutical industry too, but that doesn’t mean I go around saying “all drugs are fake and you should just inject liquefied cilantro” or something crazy like that, since just because something is bad doesn’t mean that every possible bad thing that could be done, is being done.