• SpezCanLigmaBalls@lemmy.world
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    10 months ago

    Oh wtf this was one of the drugs people used to poison themselves with? I was prescribed this a month ago because the rheumatologist told me is the safest drug for auto immune issues although I still need to take mehtylprednisolone every few months due to spinal inflammation that messes with nerves.

    • FaceDeer@kbin.social
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      10 months ago

      Don’t worry, a key part of toxicity is the dosage. If you’re following a prescription from an actual doctor instead of taking handfuls of horse medication at the behest of extremist politicians you’re fine.

      • SomeoneElse@lemmy.ca
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        10 months ago

        I followed my doctors advice (400mg daily for 15 years) and got retinol toxicity anyway. Now I have permanent damage to my macular, can’t take hydroxychloroquine anymore and my lupus is raging. It’s a fantastic drug, and blindness is a very very rare side effect, but for god’s sake insist on being monitored by an ophthalmologist. Current UK recommendations are an eye check before starting the medication, repeated after 5 years and then every year after that. I should have been checked 10 times in 15 years, I was checked twice.

    • Kecessa@sh.itjust.works
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      10 months ago

      It’s great if it’s used to treat what it was meant to, people started taking it because a few doctors mentioned it might help with COVID without having any proof it did.

    • Wrench@lemmy.world
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      10 months ago

      Just like Ivermectin, it has a legitimate use. But snakeoil salesmen peddled both of them as off label Covid miracle cures with zero medical trials, or even an attempt to begin one.

    • dantheclamman@lemmy.worldOP
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      10 months ago

      The hazards here were related to passing around doses, improper prescriptions from disreputable doctors, and not seeking out actual treatments for covid. If you have certain conditions and medications there can be side effects and interactions that harm health, but that your doctor should have considered. Some people who really needed hydroxychloroquine for legitimate uses like yours had trouble getting it because of shortages due to morons rushing out to get it.

    • marcos@lemmy.world
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      10 months ago

      If you take a look at the more dangerous collateral effects… and correlate with the more dangerous COVID effects, you’ll have a surprise.

      By itself, the drug is pretty safe.

  • lobut@lemmy.ca
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    10 months ago

    Remember these chuckleheads believe the vaccine is poison and you gotta be careful and they put this stuff into themselves. Apparently research is listening to Joe’s podcast.

    • billwashere@lemmy.world
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      10 months ago

      Anybody that takes medical advice from Joe Rogan deserves whatever malady or health problem they get. Literal leopardsatemyface…

    • Blackmist@feddit.uk
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      10 months ago

      “I don’t want none of that vaccine. You don’t know what’s in it!” - A guy at work on his cigarette break.

        • StorminNorman@lemmy.world
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          10 months ago

          I’m an off and on again smoker myself, and whilst I haven’t memorised all 5k+ chems in em, I sure as shit know “what’s in em”. Nicotine, which is what I desire and it is actually fairly innocuous, plus a shitload of supercharged death causing molecules. Cos I’m not an idiot and can look shit up. The ingredients for the vaccines were public knowledge. Google that shit. Still not sure about any of em? Guarantee either you or someone you know knows someone who can help…

      • 0110010001100010@lemmy.world
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        10 months ago

        I think you’re confusing this and Ivermectin. Hydroxychloroquine (as far as I know) is prescription only. Ivermectin is too technically but you can get the “livestock” version at a TSC or similar store. Which says a lot about the “not sheep” crowd taking medicine literally used for livestock.

    • drolex@sopuli.xyz
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      10 months ago

      Maybe you should think twice before posting this kind of uncompassionate drivel.

      Some of these people died because they trusted the prescription from their doctor. Not everybody is able to read and understand scientific literature, and they might have to rely on the authority of someone they trust. Some doctors believed, against all evidence, that this was the right thing to prescribe and some patients took their word for it.

        • drolex@sopuli.xyz
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          10 months ago

          I don’t know in other countries, but in France there was a sort of cult from some media around Raoult, who was, at the time, a respected name. So maybe it’s not that simple.

          People are talking about dead people and just call them morons. Without any idea of what they went through. Amazing.

          • AWildMimicAppears@lemmy.dbzer0.com
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            10 months ago

            sorry, but my empathy for those people is zero after the last few years. toddlers tantrum over masks, ignoring social distancing while partying, protesting against lockdowns while the ICUs were overfilled, spreading bullshit on social media about the vaccine and calling people nazis over the idea that mandated vaccination might be smart - i will call them morons over and over again, regardless of nationality, and will cite studys like the OP whenever someone asks why. i’ve been called worse for masking up when it wasn’t required, our little snowflakes will have to endure it.

          • afraid_of_zombies@lemmy.world
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            10 months ago

            No idea what they went through? Are you being serious? We all know what they went through. It was a global pandemic. They were reports of the virus in North Korea.

  • wewbull@feddit.uk
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    10 months ago

    That figure stems from a study published in the Nature scientific journal in 2021 which reported an 11 percent increase in the mortality rate, linked to its prescription against COVID-19, because of the potential adverse effects like heart rhythm disorders, and its use instead of other effective treatments.

    So I think what they are reporting is an estimate of people who died of COVID whilst taking this stuff and so did not undertake other forms of treatment.

    I don’t think they are saying that most of these people died as a direct result of taking the drug. (e.g. overdosing)., despite what the headline suggests.

    • modeler@lemmy.world
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      10 months ago

      Not quite. The drug causes heart irregularities in some people at therapeutic doses, and this killed some of those 17k people. It just doesn’t quantify it here.

      • dantheclamman@lemmy.worldOP
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        10 months ago

        The study does quantify the cardiac risk from HCQ. Those causes of death are included in the all-causes mortality rate previously determined by a separate meta analysis

  • TempermentalAnomaly@lemmy.world
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    10 months ago

    The amount of people not reading the article or the study is astounding.

    This is not about Trump.
    This is not about your conservative uncle.
    This is not about America only.

    This is about off label prescribing in ICU and ERs early in the pandemic with low evidence (theoretical pathways) in six countries which either gave explicit approval or unclear guidance that was interpreted as approval. It goes on to suggest that in a similar emergency future, the state agencies sould do better.

    In the absence of restriction, the number of expected HCQ-related deaths is likely to be directly related to the promotion of its prescription by scientists, physicians and health agencies. In February and March 2020, the use of this treatment was widely promoted based on preliminary reports suggesting a potential efficacy against COVID-19 [80]. For instance, the use of HCQ markedly increased from mid-March to mid-April 2020 [81], [82] in France before a temporary recommendation supporting its use by the State Council was rapidly rejected [83]. Similarly, the Food and Drug Administration (FDA) granted a temporary emergency use authorisation for HCQ on March 28th 2020, which was finally revoked on June 15th 2020 [84]. In India, HCQ was also prescribed as a curative treatment to patients with COVID-19 and as a prophylactic treatment for front-line workers based on public authority guidance [85]. Conversely, the British government promoted HCQ use only within clinical trials, explaining the absence of cohort studies reporting the use of HCQ in the United Kingdom in the present study [86]. Consistently, a cohort of a multinational network showed a wide variation in the use of HCQ between countries, with 85% in Spain, 14% in the USA and less than 2% in China [80]. The rush to administer this treatment caused supply shortages in community pharmacies, forcing the implementation of dispensing restrictions [82]. Finally, the results of observational studies and randomized trials in May and June 2020, respectively, convincingly demonstrated that HCQ was ineffective and led to an increase in adverse events [4], [5], [12], [66], [73].

    • cley_faye@lemmy.world
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      10 months ago

      This is the main point : the breach of the trust we could have in state agencies and doctors. Hopefully the lesson stick this time.

  • Socsa@sh.itjust.works
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    10 months ago

    But I’m not allowed to add caffeine powder to my yogurt anymore because one idiot died 🙄

  • BigMacHole@lemm.ee
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    10 months ago

    That’s more then all Vaccines COMBINED! Don’t let our Kids get Vaxxed! Hydrochloroquine them instead!

  • Gazumi@lemmy.world
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    10 months ago

    Donald Trump should be charged for those deaths. Sadly, it is unlikely that the families that took his advice would take out a class action. As to his comment about what have you got to lose? The court or any reasonable party simply has to read the patient information leaflet.

  • Pratai@lemmy.ca
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    10 months ago

    I’m going to be that guy to say… The world is better off from it.

    • Ifera@lemmy.world
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      10 months ago

      Nah, if it was only the stupid doing it to themselves that would be fine, but as someone on the medical field, you have no idea of how many cases I saw of little kids and elderly patients who were fed those pills by their loved ones.

      • em2@lemmy.ml
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        10 months ago

        It’s astonishing how much aoe dmg stupidity does.

      • FordBeeblebrox@lemmy.world
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        10 months ago

        One of my relatives did the same when I tested positive, even writing an rx for me and really pushing it. Never took any and this story makes me even more glad I didn’t listen to the facebook research

      • Pratai@lemmy.ca
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        10 months ago

        There’s always going to be innocent casualties. With the sheer stupidity these people possess, and the legality of them being able to breed- there is no way to avoid it.

        • Emerald@lemmy.world
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          10 months ago

          the legality of them being able to breed

          A eugenics comment? This isn’t r/antinatalism is it?

    • andrew_bidlaw@sh.itjust.works
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      10 months ago

      Many good people aren’t that savvy in all fields and have a peer pressure to try this and that, especially when disinformation is louder than truth. They can have good reasons like not making their fragile elderly ill, and there’s a gossiped ultimate cure to that. Can you blame them they choose it? They are a small part of that problem under the towering issue of grifters, fakes, conspiracies running amok.

      • Pratai@lemmy.ca
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        10 months ago

        Yeah. I can blame them. It’s 2024. We are so technology-ladened that a wealth of information is available to anyone with half a brain to look for it. There no excuse for ignorance anymore.

        • andrew_bidlaw@sh.itjust.works
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          10 months ago

          First Death came for dummies. but I didn’t care for I’m not one of them.

          There are conditions making them so completely misguided, bigoted, stupid. And, in a sense, they’d die off eventually, like we all would. But these profitable institutes of misinformation wouldn’t, so there would be even more of them with each gen if you let them thrive.

          Individual cells deformed by radiation carry a little weight over body disfunction. You can act like a leicocyte and fight them. But the source of radiation wouldn’t go away even if you slay all of them.

      • afraid_of_zombies@lemmy.world
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        10 months ago

        I have nothing against a person facing almost certain death throwing everything at a problem. If someone would throw me off a cliff I would spend my last few moments trying to learn how to fly while offering prayers to every god I can think of. What I have problem with is people who don’t do what they are supposed to do.

  • AutoTL;DR@lemmings.worldB
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    10 months ago

    This is the best summary I could come up with:


    Nearly 17,000 people may have died after taking hydroxycholoroquine during the first wave of COVID, according to a study by French researchers.

    The anti-malaria drug was prescribed to some patients hospitalized with COVID-19 during the first wave of the pandemic, “despite the absence of evidence documenting its clinical benefits,” the researchers point out in their paper, published in the February issue of Biomedicine & Pharmacotherapy.

    Now, researchers have estimated that some 16,990 people in six countries — France, Belgium, Italy, Spain, Turkey and the U.S. — may have died as a result.

    Researchers from universities in Lyon, France, and Québec, Canada, used that figure to analyze hospitalization data for COVID in each of the six countries, exposure to hydroxychloroquine and the increase in the relative risk of death linked to the drug.

    In fact, they say the figure may be far higher given the study only concerns six countries from March to July 2020, when the drug was prescribed much more widely.

    Hydroxychloroquine gained prominence partly due to French virologist Didier Raoult who had headed the Méditerranée Infection Foundation hospital, but was later removed amid growing controversy.


    The original article contains 260 words, the summary contains 187 words. Saved 28%. I’m a bot and I’m open source!

  • FontMasterFlex@lemmy.world
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    10 months ago

    “COULD HAVE”

    I’m so sick of this sort of reporting. Too many “maybe”, “might have”, “could be”. it’s just fear mongering.

    • dantheclamman@lemmy.worldOP
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      10 months ago

      ‘Could have’ is due to the range of potential estimates. The confidence interval was between 6420–20294 deaths.